OP0110 A COHORT STUDY ON THE BIDIRECTIONAL RELATIONSHIP BETWEEN PERIODONTITIS AND OSTEOARTHRITIS OVER A 15-YEAR FOLLOW-UP

Background: Recently, osteoarthritis has been proposed to be driven by complement-mediated inflammatory cascades. That is, in addition the conventional degenerative model, our knowledge of pathogenesis expanded with an inflammation-dependent theory. Objectives: To identify relationship between and periodontitis. Methods: 144,788 periodontitis patients propensity score-matched controls without history were enrolled this cohort study. A Cox proportional hazard model was used estimate risk osteoarthritis. Survival analysis utilized assess time-dependent effect on Age gender stratified susceptible subgroups. symmetrical case-control designed determine Results: Patients had higher (HR =1.15, 95% CI =1.12–1.17, P < 0.001) severe that led total knee/hip replacement =1.12, =1.03–1.21, 0.01) than controls, which (log-rank test 0.01). The significant both genders age subgroups over 30 years old (all 0.001). Among them, females (HR=1.27, = 1.13–1.42, aged 51 (HR= 1.21, =1.10-1.33, predisposed replacement. In addition, more likely have a (OR 1.11, 1.06 - 1.17, Conclusion: These findings suggest bidirectional presented osteoarthritis, including Likewise, develop following References: [1]Wang Q, Rozelle AL, Lepus CM, et al. Identification central role for complement Nat Med 2011;17:1674-9. Temoin S, Chakaki A, Askari [2]Identification oral bacterial DNA synovial fluid arthritis native failed prosthetic joints. J Clin Rheumatol 2012;18:117-21. Disclosure Interests: None declared